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and is expected to increase membership as the programme moves forward. The Consortium's goal is to develop a plan to harness the major world-wide mouse research programmes and infrastructures in a strategic and coordinated effort to undertake a broad-based, systematic genome-wide phenotyping project of knockout mice in order to provide the wider research community with a long-lasting resource of mammalian gene function information.
IMPC Steering Committee
|Medical Research Council Harwell||Steve Brown*, Ann-Marie Mallon|
|Wellcome Trust Sanger Institute||Allan Bradley, Dave Adams, Karen Kennedy|
|Helmholtz-Zentrum Muenchen||Martin Hrabe de Angelis|
|Toronto Centre for Phenogenomics||Colin McKerlie|
|Institut Clinique de la Souris||Yann Herault|
|Australian Phenomics Network||Ed Bertram|
|RIKEN BioResource Center||Yuichi Obata|
|CNR Monterotondo||Glauco Tocchini-Valentini|
|MARC Nanjing University||Xiang Gao|
|The Jackson Laboratory||Bob Braun, Leah Rae Donahue, Karen Svenson, Steve Murray|
|The Davis, Toronto, Charles River and CHORI Consortium (DTCC)||Kent Lloyd, Dave West|
|Korea Mouse Phenotype Consortium||Je Kyung Seong|
|Bayor College of Medicine||Monica Justice|
|National Laboratory Animal Center,
National Applied Research Laboratories (NLAC NARL), Taiwan
|EBI||Paul Flicek, Helen Parkinson|
|Czech centre for Phenogenomics, IMG||Radislav Sedlacek|
|Medical Research Council||Nathan Richardson, Claire Newland|
|National Institutes of Health||Colin Fletcher, Jim Battey, Jane Peterson, Eric Green, Mark Guyer|
|Wellcome Trust||Michael Dunn, Tom Collins|
|Genome Canada||Kate Swan|
|Canadian Institutes of Health Research||Eric Marcotte|
|European Commission (non-voting observer)||Irene Norstedt|
|Executive Director||Mark Moore|
|* chair of committee|
CRITERIA FOR MEMBERSHIP
- Institutional Membership
- A track record of experience in high throughput phenotyping and/or large-scale knockout mouse production, allied to the physical resources to undertake such activities, or expertise in specialized (“Secondary level”) phenotyping that would add value to the resource and database.
- For phenotyping centres, a commitment to phenotype not less than 50 lines per year, preferably rising to 100 lines per year within the lifetime of Phase I of the IMPC programme.
- For production centres, a commitment to generate not less than 50 lines per year, with the ability to distribute live mice, embryos, and sperm, preferably rising to 100 lines per year within the lifetime of Phase I of the IMPC programme.
- For Secondary level phenotyping groups, a commitment to share data with the IMPC as a whole, and deposit the data into the IMPC Database in a timely fashion.
- Agreement to work within the framework of the consortium, including commonly agreed phenotyping pipelines and IT structures.
- Demonstrable ability to provide the IT infrastructure for the local capture of production and/or phenotyping data and its upload to the IMPC data coordination centre(s).
- Agreement to the full release of data to data coordination centres according to IMPC agreed procedures and timelines.
- Agreement of production centers to provide the community access to live mice, embryos and sperm as soon as possible without intended hold backs, subject to legal or MTA restrictions.
- Payment of the membership fee.
- Funders’ Membership
- To commit to ensure their best endeavours to provide funding support to the IMPC programme commensurate with their institutions providing the requisite commitments to participation in the programme.
- To work to facilitate smooth and harmonious integration of the research networks recommendations and guidelines.
- To work to help communicate the goals and milestones of the IMPC to the wider scientific community.
- Payment of the membership fee.
- Membership Fee
- The membership fee is currently 50,000 GBP.
- The fee may be paid, in full or in part, with in-kind contributions, or adjusted in the future subject to approval of 75% of the Steering Committee.
- The membership fee shall be collected by the IMPC Administering Member and will require a separate letter of agreement to facilitate the process.
- The membership fee is non-refundable.
- Non-Voting Members and Observers
- The Steering Committee may request individuals or institutional representatives with special skills or information to join the Steering Committee meetings on an as needed basis, or for extended periods, subject to approval of the voting membership.
- Such participants will not have voting rights and may be asked to not participate in all aspects of the IMPC management and meeting discussions.