Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Map2k7 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Presenile Dementia, Kraepelin Type | Dementia | OMIM:176600 | |
Schizophrenia 19 | Cognitive impairment | OMIM:617629 | |
Monoamine Oxidase A Deficiency | Cognitive impairment | ORPHA:3057 | |
Alzheimer Disease 10 | Memory impairment, Dementia | OMIM:609636 | |
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant | Cognitive impairment, Dementia | OMIM:618564 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Map2k7.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Map2k7tm1a(EUCOMM)Wtsi | PMC7263671 |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Map2k7tm1a(EUCOMM)Wtsi | PMC6671969 |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. | PLoS biology (April 2019) | Map2k7tm1a(EUCOMM)Wtsi | PMC6459510 |
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. | Scientific data (September 2017) | Map2k7tm1a(EUCOMM)Wtsi | PMC5827107 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Map2k7tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Map2k7tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Map2k7tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
Map2k7tm42422(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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