Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased bone mineral content | Emc3tm1b(EUCOMM)Wtsi | HET | Early adult | 1.61×10-05 | ||
increased total body fat amount | Emc3tm1b(EUCOMM)Wtsi | HET | Early adult | 1.59×10-05 | ||
decreased vertical activity | Emc3tm1b(EUCOMM)Wtsi | HET | Early adult | 1.51×10-05 | ||
decreased lean body mass | Emc3tm1b(EUCOMM)Wtsi | HET | Early adult | 3.89×10-05 | ||
preweaning lethality, complete penetrance | Emc3tm1b(EUCOMM)Wtsi | HOM | Early adult | 4.24×10-05 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Emc3.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. | Investigative ophthalmology & visual science (February 2021) | Emc3tm1a(EUCOMM)Wtsi | PMC7900856 |
EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. | The Journal of clinical investigation (October 2017) | Emc3tm1a(EUCOMM)Wtsi | PMC5707157 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Emc3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Emc3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Emc3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Emc3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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