Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
embryonic lethality prior to organogenesis | Mettl3em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
preweaning lethality, complete penetrance | Mettl3em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
embryonic lethality prior to tooth bud stage | Mettl3em1(IMPC)Tcp | HOM | E12.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mettl3.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease. | Cell metabolism (April 2021) | Mettl3tm1c(KOMP)Wtsi | 33852874 |
m6A RNA methylation impacts fate choices during skin morphogenesis. | eLife (August 2020) | Mettl3tm1c(KOMP)Wtsi | PMC7535931 |
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. | Cell reports (August 2019) | Mettl3tm1a(KOMP)Wtsi | PMC6818972 |
The Role of m6A/m-RNA Methylation in Stress Response Regulation. | Neuron (July 2018) | Mettl3tm1c(KOMP)Wtsi Mettl3tm1a(KOMP)Wtsi | PMC6069762 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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MGI Allele | Allele Type | Produced |
---|---|---|
Mettl3tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Mettl3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Mettl3em1(IMPC)Tcp | Intra-exon deletion | Mice, Tissue |
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