The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| impaired glucose tolerance | Depdc5tm1b(EUCOMM)Hmgu | HET | Early adult | 9.91×10-06 | ||
| increased total body fat amount | Depdc5tm1b(EUCOMM)Hmgu | HET | Early adult | 9.11×10-05 | ||
| preweaning lethality, complete penetrance | Depdc5tm1b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| increased circulating alkaline phosphatase level | Depdc5tm1b(EUCOMM)Hmgu | HET | Early adult | 2.76×10-15 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
| Peripheral nervous system | Wholemount images | heterozygote | 100% (2 of 2) |
| Prostate gland | Wholemount images | heterozygote | 50% (1 of 2) |
| Testis | Wholemount images | heterozygote | 50% (1 of 2) |
| Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
| Aorta | N/A | heterozygote | 0.0% (0 of 2) |
| Bone | N/A | heterozygote | 0.0% (0 of 2) |
| Brain | N/A | heterozygote | 0.0% (0 of 2) |
| Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
| Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
| Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
| Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
| Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
| Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
| Eye | N/A | heterozygote | 0.0% (0 of 2) |
| Gall bladder | N/A | heterozygote | 0.0% (0 of 2) |
| Heart | N/A | heterozygote | 0.0% (0 of 2) |
| Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
| Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
| Large intestine | N/A | heterozygote | 0.0% (0 of 2) |
| Liver | N/A | heterozygote | 0.0% (0 of 2) |
| Lower urinary tract | N/A | heterozygote | 0.0% (0 of 2) |
| Lung | N/A | heterozygote | 0.0% (0 of 2) |
| Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
| Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
| Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
| Ovary | N/A | heterozygote | 0.0% (0 of 2) |
| Oviduct | N/A | heterozygote | 0.0% (0 of 2) |
| Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
| Parathyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
| Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
| Pituitary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 0.0% (0 of 2) |
| Small intestine | N/A | heterozygote | 0.0% (0 of 2) |
| Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
| Spleen | N/A | heterozygote | 0.0% (0 of 2) |
| Stomach | N/A | heterozygote | 0.0% (0 of 2) |
| Striatum | N/A | heterozygote | 0.0% (0 of 2) |
| Thymus | N/A | heterozygote | 0.0% (0 of 2) |
| Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
| Trachea | N/A | heterozygote | 0.0% (0 of 2) |
| Uterus | N/A | heterozygote | 0.0% (0 of 2) |
| Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
| White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Brain | N/A | heterozygote | 0.0% (0 of 2) |
| Brain | N/A | homozygote | 100% (2 of 2) |
| Ear | N/A | heterozygote | 0.0% (0 of 2) |
| Ear | N/A | homozygote | 0.0% (0 of 2) |
| Embryo | N/A | heterozygote | 0.0% (0 of 2) |
| Embryo | N/A | homozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | 0.0% (0 of 2) |
| Eye | N/A | homozygote | 100% (2 of 2) |
| Footplate | N/A | heterozygote | 0.0% (0 of 2) |
| Footplate | N/A | homozygote | 50% (1 of 2) |
| Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
| Forebrain | N/A | homozygote | 100% (2 of 2) |
| Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
| Forelimb | N/A | homozygote | 50% (1 of 2) |
| Handplate | N/A | heterozygote | 0.0% (0 of 2) |
| Handplate | N/A | homozygote | Not available |
| Head | N/A | heterozygote | 0.0% (0 of 2) |
| Head | N/A | homozygote | 100% (2 of 2) |
| Heart | N/A | heterozygote | 0.0% (0 of 2) |
| Heart | N/A | homozygote | 50% (1 of 2) |
| Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
| Hindbrain | N/A | homozygote | 100% (2 of 2) |
| Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
| Hindlimb | N/A | homozygote | 100% (2 of 2) |
| Liver | N/A | heterozygote | 0.0% (0 of 2) |
| Liver | N/A | homozygote | 0.0% (0 of 2) |
| Lung | N/A | heterozygote | 0.0% (0 of 2) |
| Lung | N/A | homozygote | Not available |
| Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
| Mandibular process | N/A | homozygote | Not available |
| Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
| Maxillary process | N/A | homozygote | Not available |
| Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
| Midbrain | N/A | homozygote | 100% (2 of 2) |
| Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
| Oral cavity | N/A | homozygote | Not available |
| Skin | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | homozygote | 100% (2 of 2) |
| Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
| Tail somite | N/A | homozygote | 100% (2 of 2) |
| Tail | N/A | heterozygote | 0.0% (0 of 2) |
| Tail | N/A | homozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.67% (4 of 598) |
| aorta | 0.17% (1 of 598) |
| bone | 0.0% |
| brain | 0.84% (5 of 598) |
| brainstem | 0.33% (2 of 598) |
| brown adipose tissue | 0.0% |
| cartilage tissue | 0.17% (1 of 598) |
| cerebellum | 0.5% (3 of 598) |
| cerebral cortex | 0.33% (2 of 598) |
| esophagus | 1.66% (7 of 422) |
| eye | 0.0% |
| gall bladder | 0.0% |
| heart | 0.33% (2 of 598) |
| hippocampus | 0.5% (3 of 598) |
| hypothalamus | 0.33% (2 of 598) |
| kidney | 4.52% (27 of 598) |
| large intestine | 5.35% (32 of 598) |
| liver | 0.0% |
| lower urinary tract | 0.17% (1 of 598) |
| lung | 0.33% (2 of 598) |
| lymph node | 0.17% (1 of 598) |
| mammary gland | 0.0% |
| olfactory lobe | 0.33% (2 of 598) |
| oral epithelium | 0.0% |
| ovary | 0.17% (1 of 598) |
| oviduct | 0.0% |
| pancreas | 0.84% (5 of 598) |
| parathyroid gland | 0.17% (1 of 576) |
| peripheral nervous system | 0.33% (2 of 598) |
| peyers patch | 0.0% |
| pituitary gland | 0.17% (1 of 598) |
| prostate gland | 2.17% (13 of 598) |
| skeletal muscle | 0.0% |
| skin | 0.17% (1 of 598) |
| small intestine | 5.35% (32 of 598) |
| spinal cord | 0.5% (3 of 598) |
| spleen | 0.5% (3 of 598) |
| stomach | 3.68% (22 of 598) |
| striatum | 0.5% (3 of 598) |
| testis | 1% (6 of 598) |
| thymus | 0.17% (1 of 598) |
| thyroid gland | 3.01% (18 of 598) |
| trachea | 0.5% (3 of 598) |
| uterus | 0.33% (2 of 598) |
| vascular system | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| brain | 1.17% (6 of 511) |
| ear | 0.2% (1 of 511) |
| embryo | 0.39% (2 of 512) |
| eye | 0.2% (1 of 511) |
| footplate | 0.2% (1 of 511) |
| forebrain | 0.2% (1 of 511) |
| forelimb | 0.2% (1 of 511) |
| handplate | 0.2% (1 of 511) |
| head | 0.98% (5 of 511) |
| heart | 0.2% (1 of 511) |
| hindbrain | 1.17% (6 of 511) |
| hindlimb | 0.2% (1 of 511) |
| liver | 0.2% (1 of 506) |
| lung | 0.2% (1 of 506) |
| mandibular process | 0.2% (1 of 511) |
| maxillary process | 0.2% (1 of 511) |
| midbrain | 0.2% (1 of 511) |
| oral cavity | 0.2% (1 of 506) |
| skin | 0.2% (1 of 511) |
| tail | 0.2% (1 of 511) |
| tail somite group | 0.2% (1 of 511) |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
XRay Images Whole Body Dorso Ventral
10 Images
M-Mode Images
28 Images
LacZ images wholemount
8 Images
XRay Images Whole Body Lateral Orientation
10 Images
XRay Images Skull Dorso Ventral Orientation
10 Images
LacZ Images Wholemount
4 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Depdc5 by orthology or direct annotation.
| Disease | Similarity of phenotypes |
Matching phenotypes | Source |
|---|---|---|---|
| Autosomal Dominant Epilepsy With Auditory Features | ORPHA:101046 | ||
| Epilepsy, Familial Focal, With Variable Foci 1 | OMIM:604364 | ||
| Autosomal Dominant Nocturnal Frontal Lobe Epilepsy | ORPHA:98784 | ||
| Familial Focal Epilepsy With Variable Foci | ORPHA:98820 |
The table below shows human diseases predicted to be associated to Depdc5 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Depdc5.
There are 7 publications which use IMPC produced mice or data.
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| MGI Allele | Allele Type | Produced |
|---|---|---|
| Depdc5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
| Depdc5tm1c(EUCOMM)Hmgu | Wild type floxed exon (post-Flp) | Mice |
| Depdc5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
| Depdc5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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