Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal embryo size | Mapkap1tm1b(EUCOMM)Wtsi | HOM | E12.5 | 0.00 | ||
decreased total retina thickness | Mapkap1tm1a(EUCOMM)Wtsi | HET | Early adult | 3.26×10-05 | ||
preweaning lethality, complete penetrance | Mapkap1tm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
dilated heart left ventricle | Mapkap1tm1b(EUCOMM)Wtsi | HET | Early adult | 4.62×10-05 | ||
increased cornea thickness | Mapkap1tm1a(EUCOMM)Wtsi | HET | Early adult | 3.38×10-05 | ||
preweaning lethality, complete penetrance | Mapkap1tm1a(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
prenatal lethality prior to heart atrial septation | Mapkap1tm1b(EUCOMM)Wtsi | HOM | E15.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | Wholemount images | heterozygote | 100% (2 of 2) |
Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
Cerebral cortex | Wholemount images | heterozygote | 100% (2 of 2) |
Heart | Wholemount images | heterozygote | 100% (2 of 2) |
Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
Olfactory lobe | Wholemount images | heterozygote | 100% (2 of 2) |
Oviduct | Wholemount images | heterozygote | 50% (1 of 2) |
Pancreas | Wholemount images | heterozygote | 100% (2 of 2) |
Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
Peripheral nervous system | Wholemount images | heterozygote | 100% (2 of 2) |
Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
Trachea | Wholemount images | heterozygote | Ambiguous |
Trigeminal V nerve | Wholemount images | heterozygote | 100% (2 of 2) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Bone | N/A | heterozygote | 0.0% (0 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cecum | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | Not available |
Gall bladder | N/A | heterozygote | 0.0% (0 of 2) |
Large intestine | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Pituitary gland | N/A | heterozygote | 100% (2 of 2) |
Prostate gland | N/A | heterozygote | 0.0% (0 of 2) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Small intestine | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
Stomach | N/A | heterozygote | 0.0% (0 of 2) |
Testis | N/A | heterozygote | 50% (1 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Uterus | N/A | heterozygote | 0.0% (0 of 2) |
Vas deferens | N/A | heterozygote | 50% (1 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Heart atrium | N/A | heterozygote | 100% (2 of 2) |
Axial skeleton | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 100% (2 of 2) |
Central nervous system ganglion | N/A | heterozygote | Ambiguous |
Cranium | N/A | heterozygote | 100% (2 of 2) |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | heterozygote | Ambiguous |
Embryo | N/A | heterozygote | 100% (2 of 2) |
Outer ear | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 100% (2 of 2) |
Femur pre-cartilage condensation | N/A | heterozygote | 0.0% (0 of 2) |
Footplate | N/A | heterozygote | 0.0% (0 of 2) |
Forearm | N/A | heterozygote | Ambiguous |
Forebrain | N/A | heterozygote | 100% (2 of 2) |
Forelimb | N/A | heterozygote | Ambiguous |
Fronto-nasal process | N/A | heterozygote | 100% (2 of 2) |
Gut | N/A | heterozygote | Ambiguous |
Handplate | N/A | heterozygote | 0.0% (0 of 2) |
Head mesenchyme | N/A | heterozygote | Ambiguous |
Head | N/A | heterozygote | 100% (2 of 2) |
Heart ventricle | N/A | heterozygote | 100% (2 of 2) |
Heart | N/A | heterozygote | 100% (2 of 2) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Humerus pre-cartilage condensation | N/A | heterozygote | Ambiguous |
Inner ear | N/A | heterozygote | Ambiguous |
Intestine | N/A | heterozygote | Ambiguous |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower leg | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | heterozygote | Ambiguous |
Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
Mesonephros of female | N/A | heterozygote | 0.0% (0 of 2) |
Mesonephros of male | N/A | heterozygote | Ambiguous |
Metanephros | N/A | heterozygote | Ambiguous |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Nasal septum | N/A | heterozygote | 100% (2 of 2) |
Nose | N/A | heterozygote | 0.0% (0 of 2) |
Notochord | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
Outflow tract | N/A | heterozygote | Ambiguous |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
N/A | heterozygote | 100% (2 of 2) | |
Pharynx | N/A | heterozygote | Ambiguous |
Radius-ulna pre-cartilage condensation | N/A | heterozygote | Ambiguous |
Rib pre-cartilage condensation | N/A | heterozygote | Ambiguous |
Skeleton | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Stomach | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
Tail | N/A | heterozygote | 0.0% (0 of 2) |
Thoracic vertebral cartilage condensation | N/A | heterozygote | Ambiguous |
Tongue | N/A | heterozygote | 0.0% (0 of 2) |
Trachea | N/A | heterozygote | Ambiguous |
Trunk mesenchyme | N/A | heterozygote | 0.0% (0 of 2) |
Umbilical artery embryonic part | N/A | heterozygote | 0.0% (0 of 2) |
Umbilical vein embryonic part | N/A | heterozygote | 0.0% (0 of 2) |
Upper arm | N/A | heterozygote | Ambiguous |
Upper leg | N/A | heterozygote | 0.0% (0 of 2) |
Urinary system | N/A | heterozygote | Ambiguous |
Vibrissa | N/A | heterozygote | 0.0% (0 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.67% (4 of 598) |
aorta | 0.17% (1 of 598) |
bone | 0.0% |
brain | 0.84% (5 of 598) |
brainstem | 0.33% (2 of 598) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.17% (1 of 598) |
cecum | 5.73% (22 of 384) |
cerebellum | 0.5% (3 of 598) |
cerebral cortex | 0.33% (2 of 598) |
esophagus | 1.66% (7 of 422) |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.33% (2 of 598) |
hippocampus | 0.5% (3 of 598) |
hypothalamus | 0.33% (2 of 598) |
kidney | 4.52% (27 of 598) |
large intestine | 5.35% (32 of 598) |
liver | 0.0% |
lower urinary tract | 0.17% (1 of 598) |
lung | 0.33% (2 of 598) |
lymph node | 0.17% (1 of 598) |
mammary gland | 0.0% |
olfactory lobe | 0.33% (2 of 598) |
oral epithelium | 0.0% |
ovary | 0.17% (1 of 598) |
oviduct | 0.0% |
pancreas | 0.84% (5 of 598) |
parathyroid gland | 0.17% (1 of 576) |
peripheral nervous system | 0.33% (2 of 598) |
peyers patch | 0.0% |
pituitary gland | 0.17% (1 of 598) |
prostate gland | 2.17% (13 of 598) |
skeletal muscle | 0.0% |
skin | 0.17% (1 of 598) |
small intestine | 5.35% (32 of 598) |
spinal cord | 0.5% (3 of 598) |
spleen | 0.5% (3 of 598) |
stomach | 3.68% (22 of 598) |
striatum | 0.5% (3 of 598) |
testis | 1% (6 of 598) |
thymus | 0.17% (1 of 598) |
thyroid gland | 3.01% (18 of 598) |
trachea | 0.5% (3 of 598) |
trigeminal v nerve | 0.0% |
uterus | 0.33% (2 of 598) |
vas deferens | 4.56% (18 of 395) |
vascular system | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
atrium | 1.67% (1 of 60) |
axial skeleton | 1.56% (1 of 64) |
brain | 1.17% (6 of 511) |
central nervous system ganglion | 1.37% (1 of 73) |
cranium | 1.56% (1 of 64) |
dorsal root ganglion | 1.67% (1 of 60) |
ear | 0.2% (1 of 511) |
embryo | 0.39% (2 of 512) |
external ear | 1.35% (1 of 74) |
eye | 0.2% (1 of 511) |
femur pre-cartilage condensation | 1.82% (1 of 55) |
footplate | 0.2% (1 of 511) |
forearm | 0.33% (1 of 305) |
forebrain | 0.2% (1 of 511) |
forelimb | 0.2% (1 of 511) |
fronto-nasal process | 1.64% (1 of 61) |
gut | 1.69% (1 of 59) |
handplate | 0.2% (1 of 511) |
head | 0.98% (5 of 511) |
head mesenchyme | 1.67% (1 of 60) |
heart | 0.2% (1 of 511) |
heart ventricle | 1.67% (1 of 60) |
hindbrain | 1.17% (6 of 511) |
hindlimb | 0.2% (1 of 511) |
humerus pre-cartilage condensation | 1.56% (1 of 64) |
inner ear | 1.56% (1 of 64) |
intestine | 1.72% (1 of 58) |
liver | 0.2% (1 of 506) |
lower leg | 0.33% (1 of 305) |
lung | 0.2% (1 of 506) |
mandibular process | 0.2% (1 of 511) |
maxillary process | 0.2% (1 of 511) |
mesonephros of female | 1.82% (1 of 55) |
mesonephros of male | 1.82% (1 of 55) |
metanephros | 1.82% (1 of 55) |
midbrain | 0.2% (1 of 511) |
nasal septum | 1.67% (1 of 60) |
nose | 1.28% (1 of 78) |
notochord | 1.67% (1 of 60) |
oral cavity | 0.2% (1 of 506) |
outflow tract | 1.67% (1 of 60) |
pancreas | 1.82% (1 of 55) |
pericardium | 1.82% (1 of 55) |
pharynx | 1.79% (1 of 56) |
radius-ulna pre cartilage condensation | 1.56% (1 of 64) |
rib pre-cartilage condensation | 1.75% (1 of 57) |
skeleton | 1.28% (1 of 78) |
skin | 0.2% (1 of 511) |
spinal cord | 1.39% (1 of 72) |
stomach | 1.82% (1 of 55) |
tail | 0.2% (1 of 511) |
tail somite group | 0.2% (1 of 511) |
thoracic vertebral cartilage condensation | 1.82% (1 of 55) |
tongue | 1.82% (1 of 55) |
trachea | 1.69% (1 of 59) |
trunk mesenchyme | 1.67% (1 of 60) |
umbilical artery embryonic part | 1.67% (1 of 60) |
umbilical vein embryonic part | 1.67% (1 of 60) |
upper arm | 0.33% (1 of 305) |
upper leg | 0.33% (1 of 305) |
urinary system | 1.69% (1 of 59) |
vibrissa | 1.35% (1 of 74) |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Mapkap1 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mapkap1.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. | Journal of molecular cell biology (February 2019) | Mapkap1tm1c(EUCOMM)Wtsi Mapkap1tm1a(EUCOMM)Wtsi | PMC6392101 |
Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc. | Cellular & molecular immunology (January 2019) | Mapkap1tm1c(EUCOMM)Wtsi Mapkap1tm1a(EUCOMM)Wtsi | 30705387 |
Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. | Arteriosclerosis, thrombosis, and vascular biology (December 2018) | Mapkap1tm1c(EUCOMM)Wtsi Mapkap1tm1a(EUCOMM)Wtsi | 30571167 |
Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. | Journal of immunology (Baltimore, Md. : 1950) (June 2018) | Mapkap1tm1c(EUCOMM)Wtsi Mapkap1tm1a(EUCOMM)Wtsi | 29934471 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Mapkap1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
Mapkap1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Mapkap1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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