The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
| Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
|---|---|---|---|---|---|---|
| abnormal neural tube closure | Csktm2b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
| abnormal embryo turning | Csktm2b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
| abnormal retina vasculature morphology | Csktm2b(EUCOMM)Hmgu | HET | Early adult | 5.05×10-06 | ||
| preweaning lethality, complete penetrance | Csktm2b(EUCOMM)Hmgu | HOM | Early adult | 0.00 | ||
| decreased total retina thickness | Csktm2b(EUCOMM)Hmgu | HET | Early adult | 3.19×10-08 | ||
| abnormal embryo size | Csktm2b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
| abnormal embryo development | Csktm2b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 | ||
| embryonic lethality prior to tooth bud stage | Csktm2b(EUCOMM)Hmgu | HOM | E12.5 | 0.00 | ||
| abnormal retina inner nuclear layer morphology | Csktm2b(EUCOMM)Hmgu | HET | Early adult | 5.68×10-09 | ||
| embryonic growth retardation | Csktm2b(EUCOMM)Hmgu | HOM | E9.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Adrenal gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Brain | Wholemount images | heterozygote | 100% (2 of 2) |
| Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
| Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
| Cerebral cortex | Wholemount images | heterozygote | 100% (2 of 2) |
| Esophagus | Wholemount images | heterozygote | 100% (2 of 2) |
| Gall bladder | Wholemount images | heterozygote | 100% (2 of 2) |
| Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
| Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
| Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
| Large intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Liver | Wholemount images | heterozygote | 100% (2 of 2) |
| Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
| Olfactory lobe | Wholemount images | heterozygote | 100% (2 of 2) |
| Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Peyer's patch | Wholemount images | heterozygote | 100% (2 of 2) |
| Prostate gland | Wholemount images | heterozygote | 50% (1 of 2) |
| Small intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
| Stomach | Wholemount images | heterozygote | 100% (2 of 2) |
| Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
| Thymus | Wholemount images | heterozygote | 100% (2 of 2) |
| Thyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Trachea | Wholemount images | heterozygote | 100% (2 of 2) |
| Vas deferens | Wholemount images | heterozygote | 50% (1 of 2) |
| Aorta | N/A | heterozygote | 100% (2 of 2) |
| Bone | N/A | heterozygote | 100% (2 of 2) |
| Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
| Cartilage tissue | N/A | heterozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | Not available |
| Heart | N/A | heterozygote | 100% (2 of 2) |
| Lung | N/A | heterozygote | 100% (2 of 2) |
| Lymph node | N/A | heterozygote | 100% (2 of 2) |
| Mammary gland | N/A | heterozygote | Not available |
| Mesenteric lymph node | N/A | heterozygote | 100% (2 of 2) |
| Oral epithelium | N/A | heterozygote | Ambiguous |
| Ovary | N/A | heterozygote | 50% (1 of 2) |
| Oviduct | N/A | heterozygote | 50% (1 of 2) |
| Pancreas | N/A | heterozygote | 100% (2 of 2) |
| Peripheral nervous system | N/A | heterozygote | 100% (2 of 2) |
| Pituitary gland | N/A | heterozygote | 50% (1 of 2) |
| Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 100% (2 of 2) |
| Spleen | N/A | heterozygote | 100% (2 of 2) |
| Testis | N/A | heterozygote | 50% (1 of 2) |
| Trigeminal V nerve | N/A | heterozygote | 100% (2 of 2) |
| Urinary bladder | N/A | heterozygote | 100% (2 of 2) |
| Uterus | N/A | heterozygote | 50% (1 of 2) |
| Vascular system | N/A | heterozygote | 100% (2 of 2) |
| White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Heart atrium | N/A | heterozygote | 100% (2 of 2) |
| Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
| Brain | N/A | heterozygote | 100% (2 of 2) |
| Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
| Cranium | N/A | heterozygote | 100% (2 of 2) |
| Dorsal root ganglion | N/A | heterozygote | 100% (2 of 2) |
| Ear | N/A | heterozygote | 100% (2 of 2) |
| Embryo | N/A | heterozygote | 100% (2 of 2) |
| Outer ear | N/A | heterozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | 100% (2 of 2) |
| Femur pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Footplate | N/A | heterozygote | 100% (2 of 2) |
| Forearm | N/A | heterozygote | 100% (2 of 2) |
| Forebrain | N/A | heterozygote | 100% (2 of 2) |
| Forelimb | N/A | heterozygote | 100% (2 of 2) |
| Fronto-nasal process | N/A | heterozygote | 100% (2 of 2) |
| Gut | N/A | heterozygote | 100% (2 of 2) |
| Handplate | N/A | heterozygote | 100% (2 of 2) |
| Head mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Head | N/A | heterozygote | 100% (2 of 2) |
| Heart ventricle | N/A | heterozygote | 100% (2 of 2) |
| Heart | N/A | heterozygote | 100% (2 of 2) |
| Hindbrain | N/A | heterozygote | 100% (2 of 2) |
| Hindlimb | N/A | heterozygote | 100% (2 of 2) |
| Humerus pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Inner ear | N/A | heterozygote | 100% (2 of 2) |
| Intestine | N/A | heterozygote | 100% (2 of 2) |
| Liver | N/A | heterozygote | 100% (2 of 2) |
| Lower leg | N/A | heterozygote | 100% (2 of 2) |
| Lung | N/A | heterozygote | 100% (2 of 2) |
| Mandibular process | N/A | heterozygote | 100% (2 of 2) |
| Maxillary process | N/A | heterozygote | 100% (2 of 2) |
| Mesonephros of female | N/A | heterozygote | 50% (1 of 2) |
| Mesonephros of male | N/A | heterozygote | 50% (1 of 2) |
| Metanephros | N/A | heterozygote | 100% (2 of 2) |
| Midbrain | N/A | heterozygote | 100% (2 of 2) |
| Nasal septum | N/A | heterozygote | 100% (2 of 2) |
| Nose | N/A | heterozygote | 100% (2 of 2) |
| Notochord | N/A | heterozygote | 100% (2 of 2) |
| Oral cavity | N/A | heterozygote | 100% (2 of 2) |
| Outflow tract | N/A | heterozygote | 100% (2 of 2) |
| Pancreas | N/A | heterozygote | 100% (2 of 2) |
| N/A | heterozygote | 100% (2 of 2) | |
| Pharynx | N/A | heterozygote | 100% (2 of 2) |
| Radius-ulna pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Rib pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Skeleton | N/A | heterozygote | 100% (2 of 2) |
| Skin | N/A | heterozygote | 100% (2 of 2) |
| Spinal cord | N/A | heterozygote | 100% (2 of 2) |
| Stomach | N/A | heterozygote | 100% (2 of 2) |
| Tail somite | N/A | heterozygote | 100% (2 of 2) |
| Tail | N/A | heterozygote | 100% (2 of 2) |
| Thoracic vertebral cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Tongue | N/A | heterozygote | 100% (2 of 2) |
| Trachea | N/A | heterozygote | 100% (2 of 2) |
| Trunk mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Umbilical artery embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Umbilical vein embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Upper arm | N/A | heterozygote | 100% (2 of 2) |
| Upper leg | N/A | heterozygote | 100% (2 of 2) |
| Urinary system | N/A | heterozygote | 100% (2 of 2) |
| Vibrissa | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.67% (4 of 598) |
| aorta | 0.17% (1 of 598) |
| bone | 0.0% |
| brain | 0.84% (5 of 598) |
| brainstem | 0.33% (2 of 598) |
| brown adipose tissue | 0.0% |
| cartilage tissue | 0.17% (1 of 598) |
| cerebellum | 0.5% (3 of 598) |
| cerebral cortex | 0.33% (2 of 598) |
| esophagus | 1.66% (7 of 422) |
| eye | 0.0% |
| gall bladder | 0.0% |
| heart | 0.33% (2 of 598) |
| hippocampus | 0.5% (3 of 598) |
| hypothalamus | 0.33% (2 of 598) |
| kidney | 4.52% (27 of 598) |
| large intestine | 5.35% (32 of 598) |
| liver | 0.0% |
| lower urinary tract | 0.17% (1 of 598) |
| lung | 0.33% (2 of 598) |
| lymph node | 0.17% (1 of 598) |
| mammary gland | 0.0% |
| mesenteric lymph node | 0.31% (1 of 323) |
| olfactory lobe | 0.33% (2 of 598) |
| oral epithelium | 0.0% |
| ovary | 0.17% (1 of 598) |
| oviduct | 0.0% |
| pancreas | 0.84% (5 of 598) |
| parathyroid gland | 0.17% (1 of 576) |
| peripheral nervous system | 0.33% (2 of 598) |
| peyers patch | 0.0% |
| pituitary gland | 0.17% (1 of 598) |
| prostate gland | 2.17% (13 of 598) |
| skeletal muscle | 0.0% |
| skin | 0.17% (1 of 598) |
| small intestine | 5.35% (32 of 598) |
| spinal cord | 0.5% (3 of 598) |
| spleen | 0.5% (3 of 598) |
| stomach | 3.68% (22 of 598) |
| striatum | 0.5% (3 of 598) |
| testis | 1% (6 of 598) |
| thymus | 0.17% (1 of 598) |
| thyroid gland | 3.01% (18 of 598) |
| trachea | 0.5% (3 of 598) |
| trigeminal v nerve | 0.0% |
| urinary bladder | 0.0% |
| uterus | 0.33% (2 of 598) |
| vas deferens | 4.56% (18 of 395) |
| vascular system | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| atrium | 1.67% (1 of 60) |
| axial skeleton | 1.56% (1 of 64) |
| brain | 1.17% (6 of 511) |
| central nervous system ganglion | 1.37% (1 of 73) |
| cranium | 1.56% (1 of 64) |
| dorsal root ganglion | 1.67% (1 of 60) |
| ear | 0.2% (1 of 511) |
| embryo | 0.39% (2 of 512) |
| external ear | 1.35% (1 of 74) |
| eye | 0.2% (1 of 511) |
| femur pre-cartilage condensation | 1.82% (1 of 55) |
| footplate | 0.2% (1 of 511) |
| forearm | 0.33% (1 of 305) |
| forebrain | 0.2% (1 of 511) |
| forelimb | 0.2% (1 of 511) |
| fronto-nasal process | 1.64% (1 of 61) |
| gut | 1.69% (1 of 59) |
| handplate | 0.2% (1 of 511) |
| head | 0.98% (5 of 511) |
| head mesenchyme | 1.67% (1 of 60) |
| heart | 0.2% (1 of 511) |
| heart ventricle | 1.67% (1 of 60) |
| hindbrain | 1.17% (6 of 511) |
| hindlimb | 0.2% (1 of 511) |
| humerus pre-cartilage condensation | 1.56% (1 of 64) |
| inner ear | 1.56% (1 of 64) |
| intestine | 1.72% (1 of 58) |
| liver | 0.2% (1 of 506) |
| lower leg | 0.33% (1 of 305) |
| lung | 0.2% (1 of 506) |
| mandibular process | 0.2% (1 of 511) |
| maxillary process | 0.2% (1 of 511) |
| mesonephros of female | 1.82% (1 of 55) |
| mesonephros of male | 1.82% (1 of 55) |
| metanephros | 1.82% (1 of 55) |
| midbrain | 0.2% (1 of 511) |
| nasal septum | 1.67% (1 of 60) |
| nose | 1.28% (1 of 78) |
| notochord | 1.67% (1 of 60) |
| oral cavity | 0.2% (1 of 506) |
| outflow tract | 1.67% (1 of 60) |
| pancreas | 1.82% (1 of 55) |
| pericardium | 1.82% (1 of 55) |
| pharynx | 1.79% (1 of 56) |
| radius-ulna pre cartilage condensation | 1.56% (1 of 64) |
| rib pre-cartilage condensation | 1.75% (1 of 57) |
| skeleton | 1.28% (1 of 78) |
| skin | 0.2% (1 of 511) |
| spinal cord | 1.39% (1 of 72) |
| stomach | 1.82% (1 of 55) |
| tail | 0.2% (1 of 511) |
| tail somite group | 0.2% (1 of 511) |
| thoracic vertebral cartilage condensation | 1.82% (1 of 55) |
| tongue | 1.82% (1 of 55) |
| trachea | 1.69% (1 of 59) |
| trunk mesenchyme | 1.67% (1 of 60) |
| umbilical artery embryonic part | 1.67% (1 of 60) |
| umbilical vein embryonic part | 1.67% (1 of 60) |
| upper arm | 0.33% (1 of 305) |
| upper leg | 0.33% (1 of 305) |
| urinary system | 1.69% (1 of 59) |
| vibrissa | 1.35% (1 of 74) |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
VIP of right fundus
15 Images
VIP of left eye
15 Images
XRay Images Skull Dorso Ventral Orientation
12 Images
VIP of right eye
15 Images
VIP of left fundus
15 Images
LacZ Images Wholemount
26 Images
LacZ images wholemount
4 Images
XRay Images Skull Lateral Orientation
12 Images
XRay Images Whole Body Lateral Orientation
12 Images
XRay Images Whole Body Dorso Ventral
12 Images
XRay Images Forepaw
12 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Csk by phenotypic similarity.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
| MGI Allele | Allele Type | Produced |
|---|---|---|
| Csktm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
| Csktm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
| Csktm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
| Csktm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
| Csktm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter