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Phenotype: decreased heart weight

Definition
less than average weight of the heart compared to controls
Synonyms
reduced heart weight
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 67

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Ghrh
Ghrhtm1b(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 1.27×10-20
Lepr
Leprtm1b(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 MRC Harwell
IMPC		 3.64×10-19
Gh
Ghtm1.1(KOMP)Vlcg 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 4.23×10-16
Bbs5
Bbs5tm1b(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 MRC Harwell
IMPC		 1.00×10-14
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 BCM
IMPC		 7.91×10-14
Clcnkb
Clcnkbem1(IMPC)Mbp 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 6.46×10-11
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 6.55×10-11
Grin2d
Grin2dtm1a(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length		 MRC Harwell
EuroPhenome		 8.17×10-11
Phex
Phexnot yet available 		HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length		 HMGU
EuroPhenome		 1.97×10-10
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 WTSI
IMPC		 2.70×10-10
Camk1d
Camk1dem1(IMPC)Mbp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 2.86×10-10
Duox2
Duox2em1(IMPC)Mbp 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 2.71×10-08
Ppp1r12b
Ppp1r12bem1(IMPC)J 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 5.05×10-08
Rnf14
Rnf14em1(IMPC)Ccpcz 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 CCP-IMG
IMPC		 2.27×10-07
Naa10
Naa10em1(IMPC)Mbp 		HEM   Late adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 3.22×10-07
Tenm4
Tenm4em1(IMPC)Tcp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 TCP
IMPC		 4.45×10-07
Fndc3a
Fndc3aem1(IMPC)Tcp 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 TCP
IMPC		 1.06×10-06
Nucb1
Nucb1em1(IMPC)Mbp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 2.23×10-06
Dytn
Dytnem1(IMPC)J 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 3.06×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 ICS
IMPC		 3.07×10-06
Atp8b1
Atp8b1em1(IMPC)Tcp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 TCP
IMPC		 3.46×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 RBRC
IMPC		 4.33×10-06
Fbxo11
Fbxo11Jf 		HET Early adult decreased heart weight Heart weight
Heart weight/tibia length		 MRC Harwell
EuroPhenome		 4.38×10-06
Rab28
Rab28em1(IMPC)J 		HOM   Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 5.39×10-06
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 6.20×10-06
Exoc3l2
Exoc3l2em1(IMPC)J 		HET Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 6.55×10-06
Cisd2
Cisd2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length		 MRC Harwell
EuroPhenome		 9.06×10-06
Trh
Trhem1(IMPC)Tcp 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 TCP
IMPC		 9.12×10-06
Hrh4
Hrh4tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased heart weight Heart weight
Heart Weight		 ICS
IMPC		 1.07×10-05
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 1.12×10-05
Ppia
Ppiaem1(IMPC)Mbp 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 1.37×10-05
Mreg
Mregtm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 KMPC
IMPC		 1.49×10-05
Dpp8
Dpp8em1(IMPC)J 		HOM   Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 2.09×10-05
Coq2
Coq2tm1b(EUCOMM)Hmgu 		HET Early adult decreased heart weight Heart weight
Organ Weight		 MRC Harwell
IMPC		 2.12×10-05
Rab39b
Rab39bem1(IMPC)Tcp 		HEM   Late adult decreased heart weight Heart weight
Heart Weight		 TCP
IMPC		 2.17×10-05
Neurl4
Neurl4em1(IMPC)Mbp 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 2.55×10-05
Krt26
Krt26em1(IMPC)Kmpc 		HOM Late adult decreased heart weight Heart weight
Heart Weight		 KMPC
IMPC		 2.71×10-05
Tle4
Tle4em1(IMPC)Mbp 		HOM   Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 3.15×10-05
Ythdc2
Ythdc2em1(IMPC)Bay 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 BCM
IMPC		 3.42×10-05
Eif2b5
Eif2b5tm1a(EUCOMM)Wtsi 		HET Early adult decreased heart weight Heart weight
Heart weight/tibia length		 ICS
EuroPhenome		 3.66×10-05
Optn
Optntm1a(EUCOMM)Wtsi 		HET Early adult decreased heart weight Heart weight
Heart weight/tibia length		 HMGU
EuroPhenome		 4.01×10-05
Mc3r
Mc3rem1(IMPC)Mbp 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 UC Davis
IMPC		 4.06×10-05
Acta2
Acta2em1(IMPC)H 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 MRC Harwell
IMPC		 4.13×10-05
Fundc1
Fundc1tm1c(KOMP)Wtsi 		HEM   Early adult decreased heart weight Heart weight
Heart Weight		 WTSI
IMPC		 4.25×10-05
Mir96
Mir96Dmdo 		HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length		 WTSI
MGP		 4.50×10-05
Zfp593
Zfp593em1(IMPC)J 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 4.88×10-05
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 MARC
IMPC		 4.98×10-05
Nup153
Nup153em1(IMPC)J 		HET   Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 6.24×10-05
Gabrg2
Gabrg2em1(IMPC)Mbp 		HET Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 6.81×10-05
Tmem248
Tmem248tm1.1(KOMP)Vlcg 		HOM Early adult decreased heart weight Heart weight
Organ Weight		 UC Davis
IMPC		 7.20×10-05
Kctd1
Kctd1em1(IMPC)J 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 8.44×10-05
Arhgap33
Arhgap33tm1b(KOMP)Wtsi 		HET Early adult decreased heart weight Heart weight
Heart Weight		 BCM
IMPC		 8.58×10-05
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 HMGU
IMPC		 8.95×10-05
Mast1
Mast1em1(IMPC)Marc 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 MARC
IMPC		 9.39×10-05
Pcyox1l
Pcyox1lem1(IMPC)J 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 JAX
IMPC		 9.69×10-05
Adgrg7
Adgrg7tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart weight Heart weight
Heart Weight		 BCM
IMPC		 9.83×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Heart Dissection
Heart Weight
Heart weight/tibia length
Organ Weight

 Phenotype associations stats

0.75% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (56/7418)

0.24% females (17/7183) 0.59% males (42/7177)

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