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Phenotype: thick ventricular wall

Definition
increased depth of the cardiac wall of the heart ventricles
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with thick ventricular wall

Total number of significant genotype-phenotype associations: 43

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM   Early adult thick ventricular wall LVPWd
Echo		 MRC Harwell
IMPC		 3.11×10-15
Lemd3
Lemd3em1(IMPC)Bay 		HET Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 4.96×10-09
Erg
Ergem1(IMPC)Bay 		HET Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 8.51×10-09
Igfbp3
Igfbp3tm1b(KOMP)Wtsi 		HOM   Early adult thick ventricular wall LVPWd
Echo		 MRC Harwell
IMPC		 3.95×10-08
Cntn3
Cntn3em1(IMPC)Marc 		HOM   Early adult thick ventricular wall LVPWs
Echo		 MARC
IMPC		 4.69×10-07
Fbxo36
Fbxo36tm1b(KOMP)Wtsi 		HOM Early adult thick ventricular wall LVPWd
Echo		 MARC
IMPC		 4.85×10-07
Cngb3
Cngb3em1(IMPC)Ccpcz 		HOM   Early adult thick ventricular wall LVPWs
Echo		 CCP-IMG
IMPC		 5.40×10-07
Iqcb1
Iqcb1em1(IMPC)Bay 		HET Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 9.19×10-07
Oxa1l
Oxa1lem1(IMPC)Bay 		HET   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 2.52×10-06
Mdh1
Mdh1em1(IMPC)Bay 		HET Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 2.57×10-06
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM   Early adult thick ventricular wall LVAWs
Echo		 MRC Harwell
IMPC		 3.04×10-06
Cbl
Cbltm1b(EUCOMM)Hmgu 		HET   Early adult thick ventricular wall LVPWd
Echo		 ICS
IMPC		 3.29×10-06
Atp1a1
Atp1a1em1(IMPC)Ccpcz 		HET Early adult thick ventricular wall LVAWs
Echo		 CCP-IMG
IMPC		 3.80×10-06
Tmem138
Tmem138tm1b(EUCOMM)Wtsi 		HOM Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 4.04×10-06
Prdm15
Prdm15tm1b(EUCOMM)Wtsi 		HET   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 4.35×10-06
Fat3
Fat3em1(IMPC)Ccpcz 		HOM Early adult thick ventricular wall LVPWd
Echo		 CCP-IMG
IMPC		 4.71×10-06
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult thick ventricular wall LVPWs
Echo		 MRC Harwell
IMPC		 7.49×10-06
Gm614
Gm614em1(IMPC)Bay 		HET   Early adult thick ventricular wall LVPWs
Echo		 BCM
IMPC		 8.00×10-06
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 9.59×10-06
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 9.77×10-06
Gyg
Gygtm1b(KOMP)Wtsi 		HET   Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 1.13×10-05
Rxfp3
Rxfp3em1(IMPC)Bay 		HOM   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 1.14×10-05
Rnf41
Rnf41em1(IMPC)Bay 		HOM   Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 1.22×10-05
Ap3m2
Ap3m2em2(IMPC)H 		HOM   Early adult thick ventricular wall LVPWd
Echo		 MRC Harwell
IMPC		 1.80×10-05
Dhx16
Dhx16tm1b(EUCOMM)Wtsi 		HET Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 2.09×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi 		HOM   Early adult thick ventricular wall LVPWs
Echo		 BCM
IMPC		 2.76×10-05
Ucp1
Ucp1tm1b(EUCOMM)Hmgu 		HOM Early adult thick ventricular wall LVPWd
Echo		 HMGU
IMPC		 3.36×10-05
Ascc1
Ascc1em1(IMPC)Bay 		HET Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 3.44×10-05
Tonsl
Tonslem1(IMPC)Bay 		HET   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 3.86×10-05
Creld2
Creld2tm1b(EUCOMM)Hmgu 		HOM Early adult thick ventricular wall LVPWd
Echo		 MRC Harwell
IMPC		 3.87×10-05
Yipf5
Yipf5tm1b(EUCOMM)Hmgu 		HET Early adult thick ventricular wall LVPWd
Echo		 ICS
IMPC		 3.90×10-05
Ndufa6
Ndufa6em1(IMPC)Bay 		HET Early adult thick ventricular wall LVPWs
Echo		 BCM
IMPC		 4.04×10-05
Slc2a12
Slc2a12em2(IMPC)Bay 		HOM   Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 5.62×10-05
Memo1
Memo1tm1b(EUCOMM)Wtsi 		HET Early adult thick ventricular wall LVPWs
Echo		 BCM
IMPC		 6.02×10-05
Trabd2b
Trabd2bem2(IMPC)Ccpcz 		HOM Early adult thick ventricular wall LVPWd
Echo		 CCP-IMG
IMPC		 6.39×10-05
Fcrl6
Fcrl6tm1b(KOMP)Wtsi 		HOM   Early adult thick ventricular wall LVAWs
Echo		 MRC Harwell
IMPC		 7.16×10-05
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HET   Early adult thick ventricular wall LVPWd
Echo		 HMGU
IMPC		 7.95×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi 		HET   Late adult thick ventricular wall LVPWd
Echo		 ICS
IMPC		 8.03×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu 		HET Early adult thick ventricular wall LVAWs
Echo		 BCM
IMPC		 8.43×10-05
Arhgef17
Arhgef17em1(IMPC)Bay 		HOM Early adult thick ventricular wall LVPWd
Echo		 BCM
IMPC		 8.94×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.78% of tested genes with null mutations on a B6N genetic background have a phenotype association to thick ventricular wall (40/2241)

0.64% females (14/2204) 0.47% males (9/1920)

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