Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
increased cardiac muscle contraction
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 25

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
MRC Harwell
IMPC
8.36×10-11
Baiap2l2
Baiap2l2tm1a(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
4.75×10-07
Calb1
Calb1em1(IMPC)Ccpcz
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
CCP-IMG
IMPC
9.97×10-07
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.19×10-06
Bms1
Bms1tm1b(EUCOMM)Hmgu
HET   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
7.68×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
1.34×10-05
Cry1
Cry1em1(IMPC)H
HOM   Late adult increased cardiac muscle contractility Fractional Shortening
Echo
MRC Harwell
IMPC
1.55×10-05
4933430I17Rik
4933430I17Riktm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
2.26×10-05
Pard3b
Pard3btm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
2.50×10-05
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
2.62×10-05
Abitram
Abitramtm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
2.62×10-05
Izumo2
Izumo2em1(IMPC)Bay
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
2.86×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
3.49×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
CCP-IMG
IMPC
4.41×10-05
Anpep
Anpepem1(IMPC)Hmgu
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
5.29×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET   Late adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
5.81×10-05
Asb7
Asb7em1(IMPC)Ccpcz
HOM   Early adult increased cardiac muscle contractility Ejection Fraction
Echo
CCP-IMG
IMPC
6.08×10-05
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
6.26×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
8.28×10-05
Cdc26
Cdc26tm1b(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
8.44×10-05
Hectd3
Hectd3tm1(NCOM)Cmhd
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
MARC
IMPC
8.53×10-05
Babam1
Babam1em1(IMPC)Ccpcz
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
CCP-IMG
IMPC
9.69×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.05% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (22/2090)

0.34% females (7/2053) 0.51% males (9/1780)

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