Help & Documentation

What P value does the IMPC use?

Generally, the IMPC has adopted a significance level of 10-4 (P < 0.0001),  which is the one displayed in the website, unless otherwise indicated. This is the choice made when screens of thousands of genes are conducted, to maintain a false discovery rate (FDR) below 5%. Please note that the significance level for pain sensitivity data, based on 110 genes, is 10-3 (P < 0.001).

Learn more:

Read about power analysis in this paper: Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics, Nature Genetics 2015

Read about the P value choice for pain sensitivity analyses here: Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen, Pain 2021

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