New review published
A review on advances in mouse genetics for the study of human disease has recently been published in Human Molecular Genetics, authored by Steve Brown, Past Chair of the IMPC. It is a part of a collection of reviews to celebrate the 30th anniversary of the founding of the journal.
The review covers the past, present and future landscape of the role of mouse genetics in illuminating the relationship between gene and phenotype and the transformational insights that mouse genetics has brought and continue to provide to our understanding of the genetic basis of disease. It focuses on large-scale mutagenesis programmes and their role in revealing novel gene function, uncovering the dark genome and multi-morbidities, including the pivotal role of the IMPC. Moreover, it reviews the range of diversity resources that are available to elaborate gene-gene and gene-environment interactions. In addition, the increasing role of mouse genetics in deciphering the functional impact of human genetic variation is discussed. The article emphasises the value of mouse genetics as it engages cumulatively at numerous points across the translational spectrum from basic mechanistic studies to pre-clinical studies, target discovery and therapeutic development.