COVID-19

The ongoing COVID-19 pandemic has highlighted the importance of biological and biomedical research in the fight against disease and its key role in providing treatments and vaccines. At the IMPC, we know and understand how vital it is that the scientific community continues to share resources, knowledge and expertise. This page has been created to outline the resources the IMPC can offer the scientific community for COVID-19 research. You can also read our official statement for an up-to-date status of broader IMPC resources or read our blog post on the role of mouse models in COVID-19 research.

Available IMPC KO Lines

This is a curated list of IMPC alleles that can be used for COVID-19 research, including Pub Med articles illustrating their relevance. Please click ‘view data’ to visit our gene pages where you can find information on phenotypes and links for ordering mice, embryonic stem cells, target vectors and tissues (where available).

Gene Corresponding Publications IMPC KO Lines Order From Phenotyped Data Available?
Dpp4
Dipeptidyl peptidase-4
26701103
26124093
25589660
26486634
27892925
28348219
30142928
30626685

tm1a(EUCOMM)Wtsi

tm1b(EUCOMM)Wtsi

EMMA, ICS View All Data
Stat1
Signal transducer and activator transcription 1
15452265
20386712

tm1a(EUCOMM)Wtsi

tm2b(EUCOMM)Wtsi

EUMMCR, EMMA View All Data
Tmprss2
Trans membrane protease, serine 2
30626688

tm2a(EUCOMM)Hmgu

EMMA View All Data
Anpep
Aminopeptidase N
15919828

em1(IMPC)Hmgu

HMGU View All Data
Trim55
Tripartite motif-containing 5
26452100

tm2a(EUCOMM)Hmgu

tm2b(EUCOMM)Hmgu

MMRRC, BCM View All Data
Ticam2
Toll-like receptor adaptor molecule 2
28592648

em1(IMPC)H

Harwell View All Data
Adam17
ADAM Metallopeptidase Domain 17
24227843

tm1a(EUCOMM)Wtsi

EMMA View All Data
Ly6e
Lymphocyte Antigen 6 Complex, Locus E
30190477

em1(IMPC)Bay

MMRRC View All Data
Dhodh
Dihydroorotate dehydrogenase
27018887

tm1a(EUCOMM)Wtsi

tm1b(EUCOMM)Wtsi

EMMA/MMRRC, EMMA View All Data
Furin
furin (paired basic amino acid cleaving enzyme)
32293910
32216698
32057769
32275259

tm1a(EUCOMM)Wtsi

tm1b(EUCOMM)Wtsi

EMMA, Harwell View All Data
CLEC4M/ CD209L/ L-SIGN/ Cd209a
Cluster of Differentiation 209
16369534

No mice available

View All Data
Bsg/CD147
Basigin
32307653

No mice available

View All Data

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