Getting Started with IMPC

Welcome to the IMPC. This page will help you get started with using our data, show how we generate our data and when we release more! This page covers the basics and only scratches the surface. For a deeper dive into what the IMPC can offer you and your research please view our help and documentation area.

What we offer

The IMPC offers a wide range of free, open-access resources for all our users. Our phenotype data is available in the following formats:

  • Gene and Phenotype pages: All data from our phenotyping centres is QCd (Quality Controlled), analysed and processed to be displayed to anyone with an internet connection, for free! You can also order IMPC Alleles supplied by our consortium members in the Order Mice section. Enter a gene symbol or phenotype to start your search.
  • Bulk Data: For users and collaborators that want to use our data in their own custom queries we offer FTP, API and Batch Query access to our data for all your analysis needs!
  • Advanced Tools: We have built a variety of advanced tools to help view, use and analyse our data.
  • Data Collections: We have curated pages that highlight certain areas of our data that are key to a number of research areas. Examples include cardiovascular, embryo development and pain.

Our Data Standardisation

With phenotyping centers in 5 continents, we pride ourselves on the standardisation of our phenotyping protocols. This achieved by:

  • The IMPC Pipeline: We have produce a standardised pipeline which all 21 phenotyping centres follow. This ensures our data is tested, recorded and delivered the same way no matter where the mouse is located.
  • Sample Sizes: Roughly 14 homozygous knockout mice (7 female, 7 male) are phenotyped for each gene
  • Wildtype baselines: Wildtype mice are continually tested using the same protocols to provide baseline “normal” values
Click to view full infographic

View our how we generate our data page for more information or click the infographic above for a visual representation of our data pipeline.

When is our data updated?

The IMPC’s goal is to phenotype all 20,000 protein-coding genes in the mouse genome. As we systematically phenotype new knockout mice every day, we release our data in sets.

We aim to release a new dataset every quarter.

As we are continuously improving our tools, protocols and innovating procedures for new studies. To be notified about new data releases please follow our twitter account or subscribe to our newsletter.

You can also register interest in a gene to be notified when data has been released or the phenotyping status has changed.

Read next

Data Generation

Read More

How to Use Gene Pages

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