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Gene: Zfp746 MGI:1916478

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Gene Summary

Name:
zinc finger protein 746
Synonyms:
2810407L07Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 2.46×10-06
increased lean body mass Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 1.26×10-08
increased total body fat amount Zfp746tm1b(EUCOMM)Hmgu HOM Early adult 1.61×10-13

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

2 Images

View images

Human diseases caused by Zfp746 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp746 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp746

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp746.

No publications found that use IMPC mice or data for Zfp746.

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MGI Allele Allele Type Produced
Zfp746tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Zfp746tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Zfp746tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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