Data release 20.0 is now live!
This major data release includes phenotyping data for 8,707 genes from 9,393 mutant lines with around 2.4 million new data points.
A key feature of this data release is the inclusion of data for lines where phenotyping has been completed but the n-number requirements may not have been met. The standardised IMPC protocols, as specified on IMPReSS, have n-number requirements and in cases where it has not been possible to produce enough animals to meet these requirements data hasn’t been included in the data release previously. Due to updates on the IMPC mutant tracking database, GenTaR, and data processing pipelines, it is now possible to include data for these lines. A total of 1,149 genes had data included due to this feature, amounting to 3,313 new procedures across these genes. Although not all of this data would go through the data analysis pipeline as it has its own n-number requirements, there were some new phenotype calls due to this feature too. Out of these genes total of 228 had at least one phenotype call in the procedures exported due to this with hits in total of 686 parameters.
K.C. Kent Lloyd, Director of Mouse Biology Program at University of California, Davis, one of the IMPC members, has commented on this important addition: “While the IMPC has a highly stringent sample size criterion for statistical analysis of mouse phenotyping data, the public release of data that does not meet this threshold will be a welcome benefit to the research community. For example, mutant mouse lines in which only one of the sexes is subviable would not have had a complete number of mice and thus its data would not previously have been released to the public. But now these and other data with a smaller sample size are available and accessible on the website and annotated accordingly to indicate they have not been included in the statistical evaluation. The ability for researchers to now see this additional data should provide even more intriguing information on heretofore unknown gene function.”
Full data release notes can be found here: https://bit.ly/IMPC_DR20